The sulfonated calix[8]arene modified with dodecyl at the lower-rim(SC8A-12C) was synthesized to improve the solubility and stability of vitamin A(Va) in aqueous solution, and promote the percutaneous permeability of Va. Lipophilic Va is almost insoluble in water, SC8A-12C could improve solubility of Va to 1.1 mg/mL and prolong the half-life of Va in aqueous solution from 5 h to 35 h. In vitro transdermal test showed that SC8A-12C increased the transdermal amount of Va by 16.9 times. SC8A-12C also increased the solubility of various skin -care ingredients, such as phenoethylresorcinol, salicylic acid, quercetin and azelaic acid, and increased the transdermal amount of salicylic acid by 3.8 times. SC8A-12C improved the efficacy of Va through improving solubility, stability and skin permeability, and was expected to develop oil-free skin-care products of Va. In view of the SC8A-12C improving solubility of a variety of skin-care ingredients, it is expected to contribute to the development of multi-functional skin-care products.