2010/01 - 至 今，南开大学，化学学院高分子化学研究所，副教授

2013/11-2014/11，美国华盛顿大学（西雅图），化工学院，访问学者

2006/07-2009/12，南开大学，化学学院高分子化学研究所，讲师

2003/09-2006/06，南开大学，化学学院，高分子化学与物理，博士

2000/09-2003/06，天津师范大学，化学学院，化学，硕士

1. 用于疾病检测与诊断的影像材料；

2. 用于癌症和糖尿病等疾病治疗的智能载体研究；

3. 用于抗细菌感染的纳米材料。

 

1. 国家自然科学基金：依据细菌结构特征和入侵机制构建具有特异性识别与可控黏附的光动力抗菌高分子研究（编号：21474055，2015/01-2018/12），主持

2. 国家自然科学基金：用于铜绿假单胞菌识别拓扑生物高分子的构建及其与蛋白质相互作用研究（编号：21174071，2012/01-2015/12），主持

3. 国家自然科学基金：新型含生物黏附性和酶抑制活性两亲性高分子药物载体 材料的研究（编号：20804021，2009/01-2011/12），主持

4. 天津市自然科学基金：可控黏附纳米抗菌剂的构建及其抑制细菌生物膜机制研究（编号：14JYBJC29400，2014/04-2017/03），主持

5. 天津市自然科学基金：生物大分子药物黏膜智能化给药的纳米载体材料研究（编号：08JCYBJC00300，2008/04-2011/03），主持

6. 教育部博士点基金：新型鼻腔给药载体材料的研究（编号：200800551030，2009/01-2011/12），主持

 

从临床实践亟待解决的问题入手，针对特定疾病的病理特征，围绕生物医用材料的设计、合成和应用开展系统深入的研究。建立了葡萄糖敏感的基于苯硼酸的含糖共聚物的合成方法，发展一系列专一性识别功能基于BODIPY的荧光材料和有机/无机杂化抗菌材料，并系统深入研究该材料对生物体亲和性能和作用机制，为开发诊断与治疗相关疾病新型材料提供借鉴。相关研究申请专利一项，出版专著1部（参编），以第一作者或通讯作者在Biomaterials, Nanoscale, J. Control. Release, Biomacromolecules, ACS Appl. Mater. Interfaces, Acta Biomater., Nanomedicine, J. Mater. Chem. Polymer等国际期刊发表SCI论文60余篇，其中影响因子>5.0有20篇；被引用1076次。

目前担任“ISRN Medicinal Chemistry”编委，J. Am. Soc. Chem., Adv. Mater., Adv Funct. Mater., Small, Biomaterials, Biomacromolecules, Mol. Pharm., Nanomedicine, ACS Appl. Mater. Inter., J. Control. Release等国际知名期刊审稿人。

 

 

1.      Xingju Jin, Xinge Zhang*, Zhongmin Wu, Dayong Teng, Xuejiao Zhang, Yanxia Wang, Zhen Wang, Chaoxing Li. Amphiphilic random glycopolymer based on phenylboronic acid: Synthesis, characterization, and potential as glucose-sensitive matrix. Biomacromolecules, 2009, 10:1337-1345.

2.      Xiujun Gao, Xinge Zhang*, Zhongming Wu, Xuejiao Zhang, Zhen Wang, Chaoxing Li. Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein drug delivery. Journal of Controlled Release, 2009, 140:141-147.

3.      Shujun Shu, Chunyang Sun, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li. Hollow and degradable polyelectrolyte nanocapsules for protein drug delivery. Acta Biomaterialia, 2010, 6:210-217.

4.     Shujun Shu, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li. Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery. Biomaterials, 2010, 31(23):6039-6049.

5.      Xuejiao Zhang, Xinge Zhang*, Zhongming Wu, Xiujun Gao, Cui Cheng, Chaoxing Li, Zhen Wang. A novel hydrotropic β-cyclodextrin grafted hyperbranched polyglycerol copolymer for hydrophobic drug delivery. Acta Biomaterialia, 2011, 7:585-592.

6.      Zhongming Wu, Xinge Zhang*, Gonglei Guo, Chaoxing Li, Demin Yu. An injectable and glucose-sensitive nanogel for controlled insulin release. Journal of Material Chemistry, 2012, 22, 22788-22796.

7.      Zhentan Lu, Xinge Zhang*, Lin Mei, Chaoxing Li. Highly water-soluble, multivalent and target-specific BODIPY-conjugated glycopolymers for living cell. Polymer Chemistry, 2013, 4, 5743-5750.

8.      Lin Mei, Wei Zhang, Zhentan Lu, Xinge Zhang*, Yanan Wang, Yuting Luo, Chaoxing Li, Zhongming Wu, Yanxia Jia. Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria. Biomaterials, 2013, 34(38):10328-10337.

9.      Lei Sun, Xinge Zhang*, Zhongming Wu, Chao Zheng, Chaoxing Li. Oral glucose- and pH-sensitive nanocarriers for simulating insulin release in vivo. Polymer Chemistry. 2014, 5, 1999-2009.

10.   Lin Mei, Xinge Zhang*, Yanan Wang, Zhentan Lu, Yu Zhao, Chaoxing Li. Multivalent gold nanoparticles with cationic surfaces displaying enhanced antimicrobial activity. Polymer Chemistry, 2014, 5(8):3038-3044.

11.   Yanxia Wang, Xinge Zhang*, Chaoxing Li. Mucoadhesive and enzymatic inhibitory nanoparticles for transmucosal insulin delivery. Nanomedicine, 2014, 9(4):451-464.

12.   Lin Mei, Zhentan Lu, Xinge Zhang*, Chaoxing Li, Yanxia Jia. Polymer-Ag nanocomposites with enhanced antimicrobial activity against bacterial infection. ACS Applied Materials & Interfaces, 2014, 6 (18):15813–15821.

13.   Zhentan Lu, Xinge Zhang*, Yu Zhao, Yinan Xue, Zhai Tingting, Zhongming Wu, Chaoxing Li. BODIPY-based macromolecular photosensitizer with cation enhanced antibacterial activity. Polymer Chemistry, 2015, 6:302-310.

14.   Zhentan Lu, Xinge Zhang*, Zhongyu Li, Zhongming Wu, Jia Song, Chaoxing Li*. Composite copolymers hybrid silver nanoparticles: Preparation and characterization of antibacterial activity and cytotoxicity. Polymer Chemistry, 2015, 6:772-779.

15.   Qianqian Guo, Tianqi Zhang, Jinxia An, Zhongming Wu, Yu Zhao, Xiaomei Dai, Xinge Zhang*, Chaoxing Li. Block versus random amphiphilic glycopolymer nanopaticles as glucose-responsive vehicles. Biomacromolecules 2015, 16, 3345−3356.

16.   Jinxia An, Xiaomei Dai, Yu Zhao, Qianqian Guo, Zhongming Wu, Xinge Zhang*, Chaoxing Li. A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells. Polymer Chemistry, 2015, 6: 6529-6542.

17.   Jinxia An, Xiaomei Dai, Zhongming Wu, Yu Zhao, Zhentan Lu, Qianqian Guo, Xinge Zhang*, Chaoxing Li. An acid-triggered degradable and fluorescent nanoscale drug delivery system with enhanced cytotoxicity to cancer cells. Biomacromolecules, 2015, 16 (8): 2444-2454.

18.   Jinxia An, Qianqian Guo, Peng Zhang, Andrew Sinclair, Xinge Zhang*, Kan Wu, Fang Sun, Hsiang-Chieh Huang, Chaoxing Li, Shaoyi Jiang. Hierarchical design of a polymeric nanovehicle for efficient tumor regression and imaging. Nanoscale, 2016, 8(17):9318-9327.

19.   Xiaomei Dai, Qianqian Guo, Jinxia An, Peng Zhang, Yu Zhao, Tianqi Zhang, Xinge Zhang*, Chaoxing Li. Functional silver nanoparticles as the benign antimicrobial agents against multi-drug resistant bacteria.ACS Applied Materials & Interfaces, 2016, 8:25798-25807.

20.   Qianqian Guo, Yu Zhao, Xiaomei Dai, Tianqi Zhang, Yunjian Yu, Xinge Zhang,* Chaoxing Li. Functional silver nanocomposites as broad-spectrum antimicrobial and biofilm-disrupting agents. ACS Applied Materials & Interfaces, 2016, revised.