报告人：Greg G. Qiao教授 （Dept. of Chemical Engineering, Melbourne School of Engineering, The University of Melbourne, Parkville, Vic 3010, Australia）
报告题目： RAFT in Blood, MOF to Cancer and Star vs Superbugs
This talk will introduce our recently developed new platform technologies based on mordent polymer chemistry. The first example is our latest development on new methods in activating RAFT process, including photo-RAFT (Macromolecules 2015, 48, 3864), Sono-RAFT (Angew. Chem. Int. Ed. 2017, 56, 12302), Fenton-RAFT (Chem. Eur. J. 2017, 23, 7221) and blood catalyzed RAFT (Angew. Chem. Int. Ed. 2018, 57, 10288; Figure 1a). The second example will introduce our recent strategy in killing cancer cells via targeting the conditions inside the cancel cells (Nanoscales 2019, 5705, Figure 1b). The last example will be structurally nanoengineered antibacterial peptide polymers (SNAPPs) (Figure 1c) we developed, and it can kill multi-drug resistant gram-negative superbugs without using any antibiotics and without causing toxicity to healthy cells (Nature Microbiol. 2016, 1, 16162).
Figure. (a) Red blood cell catalyzed Fenton-RAFT process; (b) cancel cell with increased hydroxyl radical for targeting treatment; (c) image currently in display at Science Museum, London, showing peptide star polymers interacting with bacteria surface under fluorescent microscopy.
Professor Greg Qiao received his B.En in Donghua University in 1982 and Ph.D. at the University of Queensland in 1996. He joined the University of Melbourne in 1996 and became a full Professor in 2009. He was an Australian Research Council’s professorial Future Fellow (2012-2015). He is a Fellow of RACI and RSC. Prof Qiao was the Chair of Polymer Division of the RACI (2015-2016) and a member of ARC College of Experts (2016-2018). Prof Qiao received RACI Applied Research Award in 2017, ExxonMobil Award of Excellence for Chemical Engineering in 2015, RACI’s Polymer Division Citation in 2011 and Freehills Award in 2010. He has published > 250 journal papers and > 20 patents. His key research interests are in novel macromolecular architectures, new activation methods for RAFT process, structurally nanoengineered, antibacterial peptide polymers (SNAPPs), peptide eco polymers as alternative plastics, soft tissue engineering scaffolds, polymeric gas membranes, and chemical engineering products.