题目: Poly(2-oxazoline)s: From fundamental aspects to biomaterials
报告人: Richard Hoogenboom教授 （Supramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Belgium）
报告地点： 南开大学 蒙民伟楼 201室
The living cationic ring-opening polymerization of 2-oxazolines has been studied in great detail since its discovery in 1966. The versatility of this polymerization method allows copolymerization of a variety of 2-oxazoline monomers to give a range of tunable polymer properties that enable, for example, hydrophilic, hydrophobic, fluorophilic, as well as hard and soft materials. Moreover, the chemical versatility allows orthogonal end-group and side-chain modification of the polymers. However, this class of polymers was almost forgotten in the 1980s and 1990s because of the long reaction times and limited application possibilities. In the new millennium, a revival of poly(2-oxazline)s has arisen because of their potential use as biomaterials and thermoresponsive materials, as well as the easy access to defined amphiphilic structures for (hierarchical) selfassembly.
Recent developments from our research group that illustrate the potential of poly(2-oxazoline)s will be discussed in this lecture, ranging from fundamental studies on expanding the monomer scope and the preparation of defined high-molar mass polymers as well as functional biomaterials, including the use of poly(2-oxazoline)s as pharmaceutical excipients, pharmacokinetics, as well as the preparation of various side-chain functionalized polymers as building blocks for polymer therapeutics and hydrogel cell scaffolds.
All together, we aim to develop poly(2-oxazoline)s as biomaterials by providing in depth studies on the basic questions, such as biocompatibility and renal clearance as well as by providing proof of concept for use of poly(2-oxazoline)s for various specific applications.
Prof. Richard Hoogenboom is heading the Supramolecular Chemistry (SC) group that was founded based on his appointment as associate professor in 2010 (full professor since 2014) at Ghent University, Belgium. He obtained a PhD from Eindhoven University of Technology under supervision of Prof. Ulrich S. Schubert and performed postdoctoral research with Prof. Martin Mö ller (RWTH Aachen) and Prof. Roeland Nolte (Radboud University Nijmegen). He has published more than 350 refereed scientific articles that received 15,000+ citations (h-index 62) and is listed as inventor on 16 patent families. He is currently associate editor for European Polymer Journal and Australian Journal of Chemistry. Prof. Hoogenboom is the recipient of the inaugural RSC Polymer Chemistry award (2015), the PI IUPAC young investigator award (2016), the Prometheus award for research from Ghent University (2016) and the ACS Macromolecules/Biomacromolecules Young Investigator award (2017). Since January 2018, He is a cofounder of Avroxa BVBA that commercialized poly(2-oxazoline)s under the tradename Ultroxa® .