报告时间：2017年5月15日(周一)上午10:00

报告地点：南开大学 蒙民伟楼 201室

报告人: Toshifumi Takeuchi 教授 (Graduate School of Engineering, Kobe University)

报告题目: Molecularly Imprinted Nanomaterials for Sensing and Drug Delivery Systems

摘要： Our research group is intensively focused on the development of biomimetic/bio-inspired polymers with affinity adsorption activity, signalling functions, catalytic activity, and other bio-related functions. We use these polymers in molecular imprinting (the template-induced formation of specific recognition sites) in order to achieve molecular recognition in specific binding cavities via these bio-related functions [1]. So far, we have prepared many MIPs with high affinity, selectivity, and specific signalling functions for biologically active compounds, including herbicides, endocrine disruptors, antibiotics, nucleobases, drugs and proteins. Recently, we proposed the idea of post-imprinting modifications (PIMs), which was inspired by posttranslational modifications (PTMs) of proteins. Similar to PTMs, PIMs enhanced the functionality of MIPs in a variety of ways, specifically by forming cofactor-coupled molecularly imprinted cavities where prosthetic groups are introduced into these cavities either covalently or non-covalently to improve binding activity [2-11]. In this presentation, recent advances in PIM-based MIPs will be discussed in detail. Also I will present novel and quite unconventional long circulating MIP-based nanogels (MIP-NGs) in the blood streams capable of acquiring stealth in situ by cloaking themselves with the body's own dysopsonic proteins [12]. Since nanomaterials have been attracting attention in the fields of biomedical and life sciences, our challenge will provide a new class of drug nanocarriers for therapeutic purpose.
References
[1] Takeuchi, T., et al. Chromatography 2014, 35, 139-145 (open access).
[2] Horikawa, R., et al. Angew. Chem. Int. Ed. 2016, 55, 13023.
[3] Kuwahara, A, et al. Angew. Chem. Int. Ed. 2014, 53, 12765.
[4] Sunayama, H., et al. ACS Appl. Mater. Interfaces 2014, 6, 20003.
[5] Sunayama, H., et al. Chem. Commun. 2014, 50, 1347.
[6] Suga, Y. Chem. Commun. 2013 49, 8450.
[7] Taguchi, Y., et al. Langmuir 2012, 28, 7083.
[8] Sunayama, H., et al. Biosens. Bioelectron. 2010, 26, 458
[9]Takeda, K., et al. J. Am. Chem. Soc. 2009, 131, 8833.
[10] Takeuchi, T., et al. Org. Biomol. Chem. 2006, 4, 565.
[11] Yane, T., et al. Org. Biomol. Chem. 2006, 4, 4469.
[12] Takeuchi, T., et al. Angew. Chem. Int. Ed. 2017, in press. (DOI: 10.1002/anie.201700647)