报告题目：From Molecules to Mammal: Inventing Luminescent Nanoparticles for Biology
报告人：马萨诸塞大学医学院韩刚教授
报告时间：2018年4月11日下午2:00
报告地点：蒙民伟楼201报告厅

报告内容简介
Functional luminescent nanoparticles are promising materials for in vitro and in vivo optical imaging and therapy due to their unique optical and chemical properties. In this talk, he will present three new types of biocompatible luminescence nanoparticles. The first type of materials is upconversion nanoparticles (UCNPs). He will present new developments regarding engineering UCNPs towards photodynamic therapy, optogenetic applications in neuroscience and immunotherapy. The second type of nanoparticles is persistent luminescence nanoparticles (PLNPs). They are bioluminescence-like and possess unprecedented in vivo deep tissue energy rechargeability, outstanding signal-to-noise-ratio with no need for an excitation resource (light) during imaging, and they can be directly detected with existing imaging systems. These nanoparticles continue to emit light for minutes or hours and, in some cases, days, after turning off the excitation source. These long-lasting, light-emitting nanocrystals can provide noninvasive imaging technology for evaluating structural and functional biological processes in living animals and patients. The third is a type of organic Biodpy nanoparticles that were tailored with outstanding NIR absorbing ability. Rather than the conventional laser light needed in PDT, he will present their ultralow power lamp operable PDT applications in deep tissue tumor treatment. Finally, he will introduce a nanobug concept towards cancer treatment.

报告人简介：
Dr. Gang Han is currently an Associate Professor in the Biochemistry and Molecular Pharmacology Department at University of Massachusetts-Medical School. He received his B.Sc. and M.S. degrees in Chemistry from Nanjing University, and his Ph.D. degree in Chemistry from University of Massachusetts-Amherst. He was a postdoctoral scholar at the Molecular Foundry, Lawrence Berkeley National Lab. Dr. Han has published over 70 papers in Journals such as Nature, Nature Nanotechnology, Nature Communications, Elife, PNAS, JACS, Angewandte chemie, Advanced Materials, Nano letters, ACS Nano, which were cited over 8200 times, h-index 36.