Flexible wearable sensors have the characteristics of flexibility, comfort, and wearability, and have shown great potential in future electronic products. Despite significant efforts in developing stretchable electronic materials and structures, the development of flexible strain sensors with a wide temperature range, high sensitivity, broad detection range, and good interface stability remains challenging. Here, strain sensors with buckled structures are fabricated using high and low-temperature resistant material Ti3C2Tx MXene/graphene, PDMS 184. The conductive material Ti3C2Tx MXene/graphene exhibits excellent interface interaction with PDMS 184, addressing not only the poor compatibility issue between the conductive material and the flexible substrate, but also demonstrating good stability and cycling performance. Buckled structure improves the stretchability and linearity of strain sensors. The fabricated strain sensor is suitable for a wide temperature range (-40 to 120 C-degrees) and exhibits high stretchability (120% strain). The strain sensor demonstrates rapid response times at different temperatures: -40 (72.6 ms), 0 (62.7 ms), and 120 C-degrees (52.7 ms). The strain sensor exhibits high sensitivity at different temperatures: -40 (GF = 0.38), 0 (GF = 0.24), 40 (GF = 0.66), and 120 C-degrees (GF = 1.47). The strain sensor has a wide detection range (0.1% to 120%) and excellent cycling stability. In addition, Ti3C2Tx MXene/graphene strain sensors can accurately capture various human activities, such as blinking, speaking, finger bending, and wrist bending.