Reusable and near-infrared light-activated Zinc(II) metalated porphyrin with synergetic PDT/PTT for eradicating bacterial pneumonia
By
Duan, XZ (Duan, Xiaozhuang) [1] ; Li, J (Li, Jie) [1] ; Huang, SY (Huang, Siyuan) [1] ; Li, AR (Li, Anran) [1] ; Zhang, YF (Zhang, Yufei) [1] ; Xue, Y (Xue, Yun) [1] ; Song, XH (Song, Xianhui) [1] ; Zhang, Y (Zhang, Ye) [1] ; Hong, SH (Hong, Shihao) [1] ; Gao, HH (Gao, Huanhuan) [4] ; Wu, ZM (Wu, Zhongming) [2] , [3] ; Zhang, XE (Zhang, Xinge) [1]
Article Number
146937
Published
DEC 1 2023
Indexed
2023-12-01
Document Type
Article
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Abstract
Phototherapy is an alternative treatment for combating bacterial infections without inducing antibiotic resistance. We synthesized a reusable and NIR-responsive zinc-metalated porphyrin (DEP-BH) by designing a steady acceptor-donor-acceptor structure and expanding the pi-conjugated system with zinc coordination. Compared with traditional photosensitizers, DEP-BH exhibited remarkable and stable photodynamic and photothermal therapy properties under NIR irradiation. Owing to the hydrophobicity of porphyrin, DEP-BHs were loaded into positively charged thermosensitive liposomes. When applied on Pseudomonas aeruginosa-induced stubborn pneumonia in vivo, NIR irradiating DEP-BH@TSLs nearly treated the pneumonia caused by the biofilm and down-regulated the lung inflammatory response after the administration of 0.04 mu mol (0.28 mM for 3 times). Because of the photostability of DEP-BH, one nanotherapeutic dose can be repeated for two light treatments without multiple dosing, avoiding the wastage of resources and the operation complexity. Importantly, DEP-BH is expected to be the next generation of photosensitizers with high efficiency, representing a novel direction for the application of porphyrins.