Self-Destructive Nanoscavengers Capture and Clear Neurotoxic Soluble beta -Amyloid Aggregates
作者
Zhao, Y (Zhao, Yu) [1] , [2] ; Li, QS (Li, Qiushi) [1] ; Huang, QQ (Huang, Qingqing) [1] ; Liu, Y (Liu, Yang) [1] , [3] , [4]
文献号
2300378
在线发表
AUG 2023
已索引
2023-08-29
文献类型
Article; Early Access
摘要
Cerebral soluble beta -amyloid aggregates (sA beta s) accumulation is one of the most important causes in Alzheimer's disease (AD) progression. In order to mitigate the neurotoxicity induced by sA beta s and achieve enhanced AD therapeutic outcomes, robust sA beta s clearance become an emerging task. Herein, a self-destructive nanoscavenger (SDNS) is reported based on multifunctional peptide-polymer complexes that can capture extracellular sA beta s via hydrogen-bonding interactions and deliver them into microglial lysosomes. The internalized SDNS then occurs self-destruction within lysosomes and upregulates autophagy, thereby promoting the degradation of neurotoxic sA beta s. Importantly, the enhanced autophagy also significantly suppresses the secretion of inflammatory factors by microglia, which is induced by internalized sA beta s. Given that cerebral persistent inflammatory environment disturbs microglia-mediated phagocytosis and degradation, it is believed that this synergistic approach has valuable potential as a therapeutic strategy for AD.