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郭东升课题组 | MATERIALS HORIZONS

发布人:    发布时间:2023/03/24   浏览次数:

Triple targeting host-guest drug delivery system based on lactose-modified azocalix[4]arene for tumor ablation

作者:

Li, JJ (Li, Juan-Juan) [1] ; Rong, RX (Rong, Rui-Xue) [2] ; Yang, Y (Yang, Yan) [2] ; Hu, ZY (Hu, Zong-Ying) [1] ; Hu, B (Hu, Bing) [3] ; Zhao, YY (Zhao, Ying-Ying) [3] ; Li, HB (Li, Hua-Bin) [1] ; Hu, XY (Hu, Xin-Yue) [1] ; Wang, KR (Wang, Ke-Rang) [3] ; Guo, DS (Guo, Dong-Sheng) [1]

DOI

10.1039/d3mh00018d

在线发表

FEB 2023

已索引

2023-03-18

文献类型

Article; Early Access

摘要

Host-guest drug delivery systems (HGDDSs) have been studied in an effort to modify the characteristics of therapeutic agents through noncovalent interactions, reduce toxic side effects and improve therapeutic effects. However, it is still an important task to continuously improve the targeting ability of HGDDSs, which is conducive to the development of precision medicine. Herein, we utilize the lactose-modified azocalix[4]arene (LacAC4A) as a triple targeting drug carrier customized for antitumor purposes. LacAC4A integrates three targeting features, passive targeting through the enhancing permeability and retention effect, active targeting by the interactions of lactose and the asialoglycoprotein receptors on the surface of tumor cells, and stimuli-responsive targeting via the reduction of the azo group under a hypoxia microenvironment. After loading doxorubicin (DOX) in LacAC4A, the supramolecular nanoformulation DOX@LacAC4A clearly showed the effective suppression of tumor growth through in vivo experiments. LacAC4A can achieve effective targeting, rapid release, and improve drug bioavailability. This design principle will provide a new material for drug delivery systems.