A novel two-dimensional A-D-A acceptor named as CH8 with four electron-withdrawing end units has been successfully designed and synthesized. The enlarged conjugation in two directions renders CH8 exhibit an extremely low electron reorganization energy of 98 meV, which makes CH8 a potential candidate for outstanding organic semiconductor material. When blended with PM6, a considerate power conversion efficiency of 9.37% along with a high open-circuit voltage (V-oc) 0.889 V and low energy loss (E-loss) below 0.6 eV is achieved. These results indicate that the two-dimensional A-D-A molecule with four electron-withdrawing end units is an effective molecular design strategy to achieve lower voltage loss and also possible high performance for organic photovoltaics if ideal morphology could be achieved.