Azobenzene(azo) polymer photoactuators with fullroom-temperaturereprogrammability, reprocessability, and photo-mobility are highly desirable for large-scale applications, but their development remainsadaunting challenge. Herein,astrategy is first presented for fabricating such advanced photoactuatorsfromahigh-molecular-weightmain-chainazocrystallinepoly(ester-amide) (PEA) prepared via Michael addition polymerization. This azo PEA can be readily processed into both physically cross-linked, uniaxially oriented fibers and films with high mechanical robustness and reversible photoinduced bending/unbending atroom temperature. Importantly, the presence of both amide unit-induced hydrogen bonding andcrystallinedomains in such films and fibers endows them with dynamic, yet stable cross-linking points, which enable their easy reprogrammability under strain atroom temperatureinto various three-dimensional (3D) shapes (e.g., film helicoid and spiral ribbon, fiber spring) capable of showing completely different shapedependentphotomobilemodes. In particular, these reshaped photoactuators can maintain their accurate 3D shapes and highly reversible photoinduced motions even after being kept at 80 degrees C for 20 days or at 100 degrees C for 2 days. They can also be reprocessed and recycledfromsolution atroom temperature. Suchamultifunctionalmain-chainazocrystallinePEA can serve asaversatile platform for fabricating various photoactuators with desired 3D shapes and motion modes under mild ambient conditions.