PEGylated Mn containing MOF nanoparticles for potential immunotherapy of pancreatic cancer via manganese induced activation of anti-tumor immunity

Liu, JC (Liu, Jinchao)^{[ 1 ]} ; Yang, L (Yang, Lei)^{[ 2 ]} ; Cao, XH (Cao, Xianghui)^{[ 1 ]} ; Chen, MF (Chen, Mingfei)^{[ 1 ]} ; Li, JY (Li, Jianyao)^{[ 1 ]} ; Wang, XM (Wang, Ximo)^{[ 2 ]} ; Wu, SH (Wu, Songhai)^{[ 1,4 ]} ; Zhang, ZK (Zhang, Zhenkun)^{[ 3 ]}

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, 2021, 42, 文献号: 100409

DOI: 10.1016/j.colcom.2021.100409

摘要

Metal-organic frameworks (MOFs) are mainly used as delivering nanocarriers for other cancer therapeutic agents. We report herein that manganese (Mn) based MOF nanoparticles grafted with PEG alone have efficient therapeutic effects for lethal pancreatic tumor at the cell and animal model level. Immunity analysis suggested that Mn ions released by the MOF can increase the amount of dendritic cells of the tumor microenvironments to activate innate anti-tumor immunity.