Zinc(II)-Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process

Jia, HT (Jia, Huiting)^{[ 1 ]} ; Wang, XD (Wang, Xindong)^{[ 1 ]} ; Chen, ZM (Chen, Zhaoming)^{[ 1 ]} ; Liu, S (Liu, Shuai)^{[ 1 ]} ; Zhou, TT (Zhou, Tongtong)^{[ 1 ]} ; Zhou, H (Zhou, Hao)^{[ 2 ]} ; Guo, TY (Guo, Tianying)^{[ 1 ]}

MACROMOLECULAR BIOSCIENCE, 2021, 文献号: 2100048

DOI: 10.1002/mabi.202100048

摘要

Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn2+ complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third component to mediate polyethyleneimine with molecular weight 1.8 kDa (PEI1.8k)/DNA gene delivery system. And the effects of different structural characteristics, such as the number of pyridinamine ligands, the hydrophilic-hydrophobicity of the adjacent groups, on the in vitro transfection performance of the ternary complex are systematically investigated. This ternary hybrid system provides an effective strategy to improve the gene delivery of cationic polymers.