Degradable inorganic/polymer core-shell microspheres for pH-triggered release of indole-3-acetic acid

Zhao, LL (Zhao, Linlin)^{[ 1 ]} ; Shi, LQ (Shi, Luqing)^{[ 1 ]} ; Wang, J (Wang, Jing)^{[ 1 ]} ; Zhang, Q (Zhang, Qiang)^{[ 1 ]} ; Yang, XL (Yang, Xinlin)^{[ 2 ]} ; Lu, Y (Lu, Yan)^{[ 1 ]}

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2020, 69(5): 317-325

DOI: 10.1080/00914037.2018.1563087

摘要

The narrowly dispersed functional silica/poly(di(metacryloylooxy-1-ethoxy) methane-co-acryl amide) (SiO2/P(DMOEM-co-AAm)) core-shell microspheres were synthesized by distillation precipitation polymerization of DMOEM as a degradable crosslinker and AAm as a functional monomer with the presence of 3-(methacryloxy)propyltrimethoxysilane (MPS) modified silica microspheres as seeds. Indole-3-acetic acid (IAA) can be efficiently loaded into the microspheres with a loading capacity of 37.5% via hydrogen-bonding interaction between the carboxylic acid group of IAA and the amide groups on the surface of SiO2/P(DMOEM-co-AAm). The loaded IAA can be triggered released by pH due to the presence of pH-responsive crosslinker (DMOEM).