A host-guest drug delivery nanosystem for supramolecular chemotherapy

Hu, XY (Hu, Xin-Yue)^{[ 1 ]} ; Gao, J (Gao, Jie)^{[ 1 ]} ; Chen, FY (Chen, Fang-Yuan)^{[ 1 ]} ; Guo, DS (Guo, Dong-Sheng)^{[ 1 ]}

JOURNAL OF CONTROLLED RELEASE, 2020, 324: 124-133

DOI: 10.1016/j.jconrel.2020.05.008

摘要

Supramolecular chemotherapy is currently a new strategy to improve the therapeutic efficacy as well as overcome the side effects of traditional chemotherapy. Herein, a supramolecular chemotherapy platform based on the pegylated guanidinium-modified calix[5]arene pentadodecyl ether (GC5A-12C) nanoassembly was prepared. Three commercially available antitumor drugs: oxaliplatin, methotrexate and chlorambucil, all showed strong binding to this GC5A-12C nanocarrier. The supramolecular nanodrugs achieved higher anticancer performances compared with free drugs in cell experiments. Furthermore, the cellular uptake mechanisms and efficacy are confirmed by fluorescence imaging.