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袁直课题组 | NANOSCALE

发布人:    发布时间:2020/07/17   浏览次数:

In situself-assembled biosupramolecular porphyrin nanofibers for enhancing photodynamic therapy in tumors

Liu, Y (Liu, Yang)[ 1 ] ; Li, XM (Li, Xiaomin)[ 1 ] ; Niu, XY (Niu, Xiaoyan)[ 1 ] ; Yu, LC (Yu, Licheng)[ 1 ] ; Sha, WZ (Sha, Weizhou)[ 1 ] ; Wang, W (Wang, Wei)[ 1 ] ; Yuan, Z (Yuan, Zhi)[ 1,2 ]

NANOSCALE, 2020, 12(20): 11119-11129

DOI: 10.1039/c9nr10646d

摘要

Due to the complicated environment and high tissue hydraulic pressure in tumors that easily pumps the nanomedicines back to the systemic circulation, the concentration of released photosensitizers (PSs) retained in a tumor by a traditional nano-delivery system is very low, causing an unsatisfactory photodynamic therapy (PDT) effect. Therefore, we prepared a pH/H2O2-responsive nano-system (ZnP-OC-M) through modified porphyrin PS units with a long-unsaturated oleoyl chloride chain, and by the further introduction of hydrophilic hydroxyl groups and MnO(2)through acis-addition reaction between the unsaturated double bonds of oleoyl chloride and dilute KMnO(4)solution. Making use of the sensitivity of MnO(2)to the H(2)O(2)in the acid environment of tumor cells, ZnP-OC-M selectively realized responsive disintegration and O(2)generation. More importantly, the rich amphiphilic PS units were shedded simultaneously and spontaneously completed the self-assembly into nanofibersin situby helical stacking, which displayed a 1.85-fold higher retention effect of PSsin vivocompared with free PS groups and showed a great tumor inhibition effect in enhancing PDT. This nanosystem effectively solves the problem of the low retention abilities leading to a poor PS concentration in a tumor, prolonging the treatment time window efficiently after only a single administration and achieving the purpose of PDT enhancement.