A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides

Han, BB (Han, Bei-Bei)^{[ 1,2 ]} ; Pan, YC (Pan, Yu-Chen)^{[ 3 ]} ; Li, YM (Li, Yan-Mei)^{[ 1,2 ]} ; Guo, DS (Guo, Dong-Sheng)^{[ 3 ]} ; Chen, YX (Chen, Yong-Xiang)^{[ 2 ]}

CHEMICAL COMMUNICATIONS, 2020, 56(41): 5512-5515

DOI: 10.1039/d0cc01800g

摘要

We developed a host-guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.