Radionuclide Re-188-Loaded Photothermal Hydrogel for Cancer Theranostics

Wang, YY (Wang, Yangyun)^{[ 1 ]} ; Li, LL (Li, Linlin)^{[ 1 ]} ; Shi, XP (Shi, Xingpeng)^{[ 2 ]} ; Dong, L (Dong, Liu)^{[ 3 ]} ; Yang, YH (Yang, Yihang)^{[ 1,3 ]} ; Zhang, YJ (Zhang, Youjiu); Wu, GL (Wu, Guolin)^{[ 4 ]} ; Zhu, R (Zhu, Ran)^{[ 1 ]}

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 2020, 37(2): 文献号: 1900421

DOI: 10.1002/ppsc.201900421

摘要

Herein, an injectable photothermal hydrogel system containing a therapeutic radionuclide Re-188 is studied for combined radioisotope therapy and photothermal therapy (PTT) of cancer. A dopamine-conjugated poly(alpha,beta-aspartic acid) copolymer (PDAEA) is used to trigger a sol-gel phase transition in mixture with Fe3+ ions, rapidly forming a gel by simply mixing PDAEA and FeCl3 phosphate buffer saline solutions. The injectable hydrogel exhibits strong near-infrared light absorbance and can efficiently convert light into a heating effect for local PTT treatment. The obtained hydrogel possesses a porous 3D microstructure, and can be utilized for radionuclide loading. After the (NaReO4)-Re-188 loading, the hydrogel is intratumorally injected into the tumor of mice bearing 4T1 murine breast cancer cells for studying the tumor retention and therapeutic efficiency. In vivo results show that (NaReO4)-Re-188-loaded hydrogel exhibits significantly longer time in the tumor sites than that of free (NaReO4)-Re-188. The tumor growth of mice treated with (NaReO4)-Re-188-loaded hydrogel under near-infrared radiation is significantly inhibited compared with control groups. Therefore, the results show that the developed strategy using an injectable and biocompatible hydrogel may promote the applications of radioisotope therapy and photothermal therapy for cancer.