A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

Gao, J (Gao, Jie)^{[ 1 ]} ; Yu, HJ (Yu, Huijuan)^{[ 2 ]} ; Chen, FY (Chen, Fang-Yuan)^{[ 1 ]} ; Hu, XY (Hu, Xin-Yue)^{[ 1 ]} ; Wang, YF (Wang, Yuefei)^{[ 2 ]} ; Guo, DS (Guo, Dong-Sheng)^{[ 1 ]}

CHEMICAL COMMUNICATIONS, 2019, 55(95): 14387-14390

DOI: 10.1039/c9cc08199b

摘要

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.