Cation-induced chirality in a bifunctional metal-organic framework for quantitative enantioselective recognition

Han, ZS (Han, Zongsu)^{[ 1 ]} ; Wang, KY (Wang, Kunyu)^{[ 1 ]} ; Guo, YF (Guo, Yifan)^{[ 1 ]} ; Chen, WJ (Chen, Wenjie)^{[ 1 ]} ; Zhang, JL (Zhang, Jiale)^{[ 1 ]} ; Zhang, XR (Zhang, Xinran)^{[ 2 ]} ; Siligardi, G (Siligardi, Giuliano)^{[ 3 ]} ; Yang, SH (Yang, Sihai)^{[ 2 ]} ; Zhou, Z (Zhou, Zhen)^{[ 4 ]} ; Sun, PC (Sun, Pingchuan)^{[ 5 ]} ; Shi, W (Shi, Wei)^{[ 1 ]} ; Cheng, P (Cheng, Peng)^{[ 1 ]}

NATURE COMMUNICATIONS, 2019, 10, 文献号: 5117

DOI: 10.1038/s41467-019-13090-9

摘要

The integration of luminescence and chirality in easy-scalable metal-organic frameworks gives rise to the development of advanced luminescent sensors. To date, the synthesis of chiral metal-organic frameworks is poorly predictable and their chirality primarily originates from components that constitute the frameworks. By contrast, the introduction of chirality into the pores of metal-organic frameworks has not been explored to the best of our knowledge. Here, we demonstrate that chirality can be introduced into an anionic Zn-based metal-organic framework via simple cation exchange, yielding dual luminescent centers comprised of the ligand and Tb3+ ions, accompanied by a chiral center in the pores. This bifunctional material shows enantioselectivity luminescent sensing for a mixture of stereoisomers, demonstrated for Cinchonine and Cinchonidine epimers and amino alcohol enantiomers, from which the quantitative determination of the stereoisomeric excess has been obtained. This study paves a pathway for the design of multifunctional metal-organic framework systems as a useful method for rapid sensing of chiral molecules.