Fabrication of Polymer-Protein Hybrids
Ju, YY (Ju, Yuanyuan)[ 1,2 ] ; Zhang, Y (Zhang, Yue)[ 3 ] ; Zhao, HY (Zhao, Hanying)[ 1,2 ]
MACROMOLECULAR
RAPID COMMUNICATIONS, 2018, 39(7): 文献号: 1700737
DOI: 10.1002/marc.201700737
WOS:000429570100005
Abstract
Rapid
developments in organic chemistry and polymer chemistry promote the synthesis
of polymer-protein hybrids with different structures and biofunctionalities. In
this feature article, recent progress achieved in the synthesis of
polymer-protein conjugates, protein-nanoparticle core-shell structures, and
polymer-protein nanogels/hydrogels is briefly reviewed. The polymer-protein
conjugates can be synthesized by the "grafting-to" or the
"grafting-from" approach. In this article, different coupling
reactions and polymerization methods used in the synthesis of bioconjugates are
reviewed. Protein molecules can be immobilized on the surfaces of nanoparticles
by covalent or noncovalent linkages. The specific interactions and chemical
reactions employed in the synthesis of core-shell structures are discussed.
Finally, a general introduction to the synthesis of environmentally responsive
polymer-protein nanogels/hydrogels by chemical cross-linking reactions or
molecular recognition is provided.