功能高分子材料教育部重点实验室

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赵汉英课题组 | MACROMOLECULAR RAPID COMMUNICATIONS

发布人:功能高分子材料教育部重点实验室    发布时间:2018/04/26   浏览次数:

Fabrication of Polymer-Protein Hybrids

Ju, YY (Ju, Yuanyuan)1,2 ] Zhang, Y (Zhang, Yue)3 ] Zhao, HY (Zhao, Hanying)1,2 ]

MACROMOLECULAR RAPID COMMUNICATIONS, 2018, 39(7): 文献号: 1700737

DOI: 10.1002/marc.201700737

 WOS:000429570100005

Abstract

Rapid developments in organic chemistry and polymer chemistry promote the synthesis of polymer-protein hybrids with different structures and biofunctionalities. In this feature article, recent progress achieved in the synthesis of polymer-protein conjugates, protein-nanoparticle core-shell structures, and polymer-protein nanogels/hydrogels is briefly reviewed. The polymer-protein conjugates can be synthesized by the "grafting-to" or the "grafting-from" approach. In this article, different coupling reactions and polymerization methods used in the synthesis of bioconjugates are reviewed. Protein molecules can be immobilized on the surfaces of nanoparticles by covalent or noncovalent linkages. The specific interactions and chemical reactions employed in the synthesis of core-shell structures are discussed. Finally, a general introduction to the synthesis of environmentally responsive polymer-protein nanogels/hydrogels by chemical cross-linking reactions or molecular recognition is provided.