功能高分子材料教育部重点实验室

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郭东升课题组 | SUPRAMOLECULAR CHEMISTRY

发布人:功能高分子材料教育部重点实验室    发布时间:2018/04/19   浏览次数:

Assembly-enhanced molecular recognition of calix[6]arene

Tian, HW (Tian, Han-Wen)1 ] Pan, YC (Pan, Yu-Chen)1 ] Guo, DS (Guo, Dong-Sheng)1 ]

SUPRAMOLECULAR CHEMISTRY, 2018, 30(7): 562-567 特刊: SI

DOI: 10.1080/10610278.2017.1413243

会议: 14th International Conference on Calixarenes (Calix)

会议地点: Nankai Univ, Tianjin, PEOPLES R CHINA

会议日期: AUG 20-24, 2017

 WOS:000429099200002

Abstract

We comparatively investigated the molecular recognition of the amphiphilic derivatives of p-sulfonatocalix[n]arenes (SCnA-Rs, n=4 and 6) both in aqueous solution and at the interface of liposome. When the recognition events transfer from aqueous solution to the self-assembled interface, the binding capability of SC6A-R increases drastically, but not for SC4A-R. It originates from the conformational regulation that the complicated conformation of SC6A-R in aqueous solution was immobilized to the cone shape upon embedding SC6A-R into the liposome. The resulting cone shape is privileged to accommodate guests into its cavity. Such an assembly-enhanced molecular recognition strategy could be transferable to other macrocyclic, acyclic, artificial, and natural receptors with conformational flexibility.