Assembly-enhanced molecular recognition of calix[6]arene
Tian, HW (Tian, Han-Wen)[ 1 ] ; Pan, YC (Pan, Yu-Chen)[ 1 ] ; Guo, DS (Guo, Dong-Sheng)[ 1 ]
SUPRAMOLECULAR
CHEMISTRY, 2018, 30(7): 562-567 特刊: SI
DOI: 10.1080/10610278.2017.1413243
会议: 14th
International Conference on Calixarenes (Calix)
会议地点: Nankai
Univ, Tianjin, PEOPLES R CHINA
会议日期: AUG
20-24, 2017
WOS:000429099200002
Abstract
We
comparatively investigated the molecular recognition of the amphiphilic
derivatives of p-sulfonatocalix[n]arenes (SCnA-Rs, n=4 and 6) both in aqueous
solution and at the interface of liposome. When the recognition events transfer
from aqueous solution to the self-assembled interface, the binding capability
of SC6A-R increases drastically, but not for SC4A-R. It originates from the
conformational regulation that the complicated conformation of SC6A-R in
aqueous solution was immobilized to the cone shape upon embedding SC6A-R into
the liposome. The resulting cone shape is privileged to accommodate guests into
its cavity. Such an assembly-enhanced molecular recognition strategy could be
transferable to other macrocyclic, acyclic, artificial, and natural receptors
with conformational flexibility.