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张新歌课题组 | CHEMICAL COMMUNICATIONS

发布人:功能高分子材料教育部重点实验室    发布时间:2018/11/29   浏览次数:

Therapeutic nanoplatforms with bacteria-specific activation for directional transport of antibiotics

Yu, YJ (Yu, Yunjian)1 ] Zhang, TQ (Zhang, Tianqi)1 ] Dai, XJ (Dai, Xijuan)1 ] Dai, XM (Dai, Xiaomei)1 ] Wei, XS (Wei, Xiaosong)1 ] Zhang, XG (Zhang, Xinge)1 ] Li, CX (Li, Chaoxing)1 ]

CHEMICAL COMMUNICATIONS, 2018, 54(90): 12754-12757

DOI: 10.1039/c8cc06398b

 WOS:000449496400019

Abstract

An entirely new strategy is explored for directional transport delivery of antibiotics to bacteria utilizing a bacteria-activated nanoplatform. The nanoplatform can effectively prevent the premature leakage of the therapeutic payload, but release was triggered when the nanoplatforms adhere to bacteria, promising potential applications for the delivery of a wide-range of antimicrobials.