A conveniently synthesized Pt (IV) conjugated alginate nanoparticle with ligand self-shielded property for targeting treatment of hepatic carcinoma

Wang, XY (Wang, Xinyu)^[ 1 ] ; Chang, Z (Chang, Zhi)^[ 3 ] ; Nie, X (Nie, Xin)^[ 4 ] ; Li, YY (Li, Yingying)^[ 1 ] ; Hu, ZP (Hu, ZhenPeng)^[ 1 ] ; Ma, JL (Ma, Jinlong)^[ 1 ] ; Wang, W (Wang, Wei)^[ 1 ] ; Song, T (Song, Teng)^[ 3 ] ; Zhou, P (Zhou, Pei)^[ 3 ] ; Wang, HQ (Wang, Huaqing)^[ 3 ] ; Yuan, Z (Yuan, Zhi)^[ 1,2 ] 

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2019, 15(1): 153-163

DOI: 10.1016/j.nano.2018.09.012

 WOS:000452546700014

Abstract

The clinical translation remains a major challenge for platinumdrug loaded nanoparticle due to the complexity of composition and preparation. Here we employed only three ingredients to prepare Pt (IV) prodrug-loaded ligand-induced self-assembled nanoparticles (GA-ALG@Pt NPs) via facile one-pot route for liver tumor treatment. GA-ALG@Pt NPs were found equipped with intelligently ligand self-shielded property in which the internal GA could be induced to expose by initial cellular recognition, resulting in strengthened cellular uptake (20%-30%) and prolonged blood circulation time (3.43 times). Appreciable tumor targeting ability (2 times) and especially tumor selectivity (2.5 times) were obtained.Glutathione-triggered release of therapeutic agent generated satisfactory antitumor effect. Bio-safety is also a distinguishing feature of GA-ALG@ Pt NPs that greatly relief the nephrotoxicity and systematic toxicity of cisplatin. This conveniently synthesized nanoparticle processes superior targeting capacity and biosecurity, supplying an effective approach to translational cancer therapy in the future. (C) 2018 Elsevier Inc. All rights reserved.