Synthetic Fluorescent Nanoplatform Based on Benzoxaborole for Broad-Spectrum Inhibition of Bacterial Adhesion to Host Cells

Yu, YJ (Yu, Yunjian)^[ 1 ] ; Dai, XJ (Dai, Xijuan)^[ 1 ] ; Wei, XS (Wei, Xiaosong)^[ 1 ] ; Dai, XM (Dai, Xiaomei)^[ 1 ] ; Yu, C (Yu, Cong)^[ 1 ] ; Duan, XZ (Duan, Xiaozhuang)^[ 1 ] ; Zhang, XG (Zhang, Xinge)^[ 1 ] ; Li, CX (Li, Chaoxing)^[ 1 ]

CHEMISTRY OF MATERIALS, 2018, 30(24): 8795-8803

DOI: 10.1021/acs.chemmater.8b03346

Abstract

The rising prevalence of antibiotic-resistant bacteria pathogens has attracted increasing concern in the whole world. The antiadhesion strategy without triggered bacterial resistance is currently considered a promising alternative to treat bacteria-induced infections. Here, we developed a novel bacteria-binding florescent polymeric nanoplatform for nonlethal antiadhesion therapy of bacterial infections. This versatile platform will allow simultaneous bacterial agglutination and fluorescent reporting for both Gram-positive and Gram-negative bacteria by taking advantage of strong interaction between the benzoxaborole groups and diol moieties on bacterial surfaces. Furthermore, impressive performance of inhibiting biofilm formation was entirely shown in the generic cell-binding glues. The trapping nanoparticles were capable of taking invasive bacteria pathogens away from the infected host cells with negligible damage to neither bacterial nor host cells, which will not trigger drug resistance, indicating a far-reaching future of the potential application for antiadhesion therapy of whole-bacterial infection diseases.