功能高分子材料教育部重点实验室

近期发表论文

郭东升课题组 | ORGANIC CHEMISTRY FRONTIERS

发布人:功能高分子材料教育部重点实验室    发布时间:2018/10/12   浏览次数: 85 次

Differential calixarene receptors create patterns that discriminate glycosaminoglycans

Zheng, Z (Zheng, Zhe)1 ] Geng, WC (Geng, Wen-Chao)1 ] Gao, J (Gao, Jie)1 ] Mu, YJ (Mu, Yi-Jiang)1 ] Guo, DS (Guo, Dong-Sheng)1,2 ]

ORGANIC CHEMISTRY FRONTIERS, 2018, 5(18): 2685-2691

DOI: 10.1039/c8qo00606g

 WOS:000445221000009

Abstract

On account of the challenge of discriminating glycosaminoglycans (GAGs) via optical methods, we designed a fluorescence displacement sensing array. The sensing array is composed of four reporter pairs, where four positively charged calixarene derivatives act as receptors, and eosin Y as the reporter dye. The complexation of calixarenes quenches the fluorescence of the dye, and thereby, the competitive complexation of the analytes gives rise to fluorescence regeneration, achieving the switch-on sensing. By implementing an indicator displacement assay of four reporter pairs towards six GAGs, we obtained fluorescence response patterns for each GAG. The subsequent chemometric analysis makes the fluorescence discrimination of GAGs well realized. Besides the sensing selectivity, the present reporter pairs also exhibit high sensitivity.