功能高分子材料教育部重点实验室

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史林启课题组 | BIOMACROMOLECULES

发布人:功能高分子材料教育部重点实验室    发布时间:2018/07/05   浏览次数: 530 次

Photoswitchable Micelles for the Control of Singlet-Oxygen Generation in Photodynamic Therapies

Zhai, Y (Zhai, Yan)1 ] Busscher, HJ (Busscher, Henk J.)3,4 ] Liu, Y (Liu, Yong)3,4 ] Zhang, ZK (Zhang, Zhenkun)1 ] van Kooten, TG (van Kooten, Theo G.)3,4 ] Su, LZ (Su, Linzhu)1 ] Zhang, YM (Zhang, Yumin)5,6 ] Liu, JJ (Liu, Jinjian)5,6 ] Liu, JF (Liu, Jianfeng)5,6 ] An, YL (An, Yingli)1 ] Shi, LQ (Shi, Linqi)1,2 ] 

BIOMACROMOLECULES, 2018, 19(6): 2023-2033 特刊: SI

DOI: 10.1021/acs.biomac.8b00085

 WOS:000435226200025

Abstract

Inadvertent photosensitizer-activation and singlet-oxygen generation hampers clinical application of photodynamic therapies of superficial tumors or subcutaneous infections. Therefore, a reversible photoswitchable system was designed in micellar nanocarriers using ZnTPP as a photosensitizer and BDTE as a photoswitch. Singlet-oxygen generation upon irradiation didnot occur in closed-switch micelles with ZnTPP/BDTE feeding ratios >1:10. Deliberate switch closure/opening within 65-80 min was possible through thin layers of porcine tissue in vitro, increasing for thicker layers. Inadvertent opening of the switch by simulated daylight, took several tens of hours. Creating deliberate cell damage and prevention of inadvertent damage in vitro and in mice could be done at lower ZnTPP/BDTE feeding ratios (1:5) in open-switch micelles and at higher irradiation intensities than inferred from chemical clues to generate singlet-oxygen. The reduction of inadvertent photosensitizer activation in micellar nanocarriers, while maintaining the ability to kill tumor cells and infectious bacteria established here, brings photo dynamic therapies closer to clinical application.