功能高分子材料教育部重点实验室

近期发表论文

郭天瑛课题组 | ACS BIOMATERIALS SCIENCE & ENGINEERING

发布人:功能高分子材料教育部重点实验室    发布时间:2017/08/04   浏览次数: 314 次

Biodegradable Highly Branched Poly(beta-Amino Ester)s for Targeted Cancer Cell Gene Transfection

Liu, S (Liu, Shuai)1,2 ] Gao, YS (Gao, Yongsheng)1 ] Sigen, A (Sigen, A.)1 ] Zhou, DZ (Zhou, Dezhong)1 ] Greiser, U (Greiser, Udo)1 ] Guo, TY (Guo, Tianying)2 ] Guo, R (Guo, Rui)3 ] Wang, WX (Wang, Wenxin)1 ]

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 3(7): 1283-1286

DOI: 10.1021/acsbiomaterials.6b00503

 WOS:000405447700010

Abstract

To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(beta-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESSFA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.