功能高分子材料教育部重点实验室

近期发表论文

赵汉英课题组 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

发布人:功能高分子材料教育部重点实验室    发布时间:2017/07/31   浏览次数: 184 次

Co-assembly of Patchy Polymeric Micelles and Protein Molecules

Fan, WJ (Fan, Weijing)1 ] Liu, L (Liu, Li)1 ] Zhao, HY (Zhao, Hanying)1,2 ]

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56(30): 8844-8848

DOI: 10.1002/anie.201704955

 WOS:000405308500044

Abstract

The development in the synthesis and self-assembly of patchy nanoparticles has resulted in the creation of complex hierarchical structures. Co-assembly of polymeric nanoparticles and protein molecules combines the advantages of polymeric materials and biomolecules, and will produce new functional materials. Co-assembly of positively charged patchy micelles and negatively charged bovine serum albumin (BSA) molecules is investigated. The patchy micelles, which were synthesized using block copolymer brushes as templates, leads to co-assembly with protein molecules into vesicular structures. The average size of the assembled structures can be controlled by the molar ratio of BSA to patchy micelles. The assembled structures are dissociated in the presence of trypsin. The protein-polymer hybrid vesicles could find potential applications in medicine.